Talent is the cornerstone of today’s global economy. It drives corporate location decisions, encourages innovative urban planning and inspired entrepreneurship. In essence, talent is the key to economic growth. If regions – such as San Diego – want to get ahead, they must have the worksforce to compete. This study looks at San Diego’s standing among peer U.S. metropolitan regions with regard to highly-skilled scientific, engineering, and tech talent. By analyzing its strengths and addressing challenges, San Diego can better improve its edge in attracting and retaining talent and investment.